Veno-occlusive disease (VOD), also called sinusoidal obstruction syndrome (SOS), is a potentially life-threatening complication of hematopoietic stem cell transplantation (HSCT) conditioning or high-dose non-transplant chemotherapy. VOD/SOS with multi-organ dysfunction (MOD) is associated with a mortality rate of > 80% (Richardson, Aggarwal et al). The VOD Health Economics and Outcomes Research (HEOR) team at NOVEL Health Strategies recently conducted an exploratory analysis of all-payer national database to develop hypothesis on burden of VOD in Medicaid patients.
Medicaid VOD patients have very long hospital length of stay (LOS)
The mean hospital LOS for VOD Medicaid patients was 53.47 and median was 48 days. While all VOD patients had relatively long LOS, Medicaid patients had significantly longer duration of hospitalization.
Medicaid VOD patients hospital charges were very high, suggesting significant resource utilization by VOD patients
The mean hospital charges for VOD were $1.54 million and median was $0.95 million.
Hypothesis:
Medicaid patients with VOD pose significantly high burden on healthcare system, there is an urgent need for better treatment management.
Notable References:
- Systematic review of defibrotide studies in the treatment of veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) https://www.nature.com/articles/s41409-019-0474-8 (SLR by NOVEL Health Strategies and Jazz Pharmaceuticals)
- PRO25 Trend in Hospital Length of Stay, Costs and Comorbidities in Patients with Veno-Occlusive Disease (VOD): Analysis of National in-Patient Hospital Database https://www.valueinhealthjournal.com/article/S1098-3015(21)01227-4/fulltext (Analysis by NOVEL Health Strategies)
